An integrated route to identifying new pathogenesis-based therapeutic approaches for trisomy 21 (Down Syndrome) following the thought of Jérôme Lejeune

Pierluigi Strippoli^1*, Maria Chiara Pelleri1^1*, Maria Caracausi¹, Lorenza Vitale¹, Allison Piovesan¹, Chiara Locatelli², Maria Chiara Mimmi³, Anna Concetta Berardi⁴, Doris Ricotta⁵, Annalisa Radeghieri⁵, Donatella Barisani⁶, Mark Basik⁷, Maria Chiara Monaco⁸, Alessandro Ghezzo¹, Marco Seri⁹, Guido Cocchi¹⁰